Wei Chen Selected Research

Catenins

2/2024	[D-Ala2, D-Leu5]-enkephalin (DADLE) provides protection against myocardial ischemia reperfusion injury by inhibiting Wnt/β-Catenin pathway.
1/2024	A Natural Small Molecule Mitigates Kidney Fibrosis by Targeting Cdc42-mediated GSK-3β/β-catenin Signaling.
1/2024	Cbfβ regulates Wnt/β-catenin, Hippo/Yap, and TGFβ signaling pathways in articular cartilage homeostasis and protects from ACLT surgery-induced osteoarthritis.
1/2024	Deficiency of Cbfβ in articular cartilage leads to osteoarthritis-like phenotype through Hippo/Yap, TGFβ, and Wnt/β-catenin signaling pathways.
11/2023	PP2 alleviates the progression of osteoarthritis by inhibiting Wnt/β-catenin and activating TGF-β/Smad signaling.
1/2023	PHGDH promotes esophageal squamous cell carcinoma progression via Wnt/β-catenin pathway.
1/2023	Astaxanthin prevents osteoarthritis by blocking Rspo2-mediated Wnt/β-catenin signaling in chondrocytes and abolishing Rspo2-related inflammatory factors in macrophages.
12/2022	EIF3H stabilizes CCND1 to promotes intrahepatic cholangiocarcinoma progression via Wnt/β-catenin signaling.
11/2022	Cancer-associated fibroblasts promote the stemness and progression of renal cell carcinoma via exosomal miR-181d-5p.
10/2022	Runx1 is a key regulator of articular cartilage homeostasis by orchestrating YAP, TGFβ, and Wnt signaling in articular cartilage formation and osteoarthritis.

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Wei Chen Research Topics

Disease

1178	Neoplasms (Cancer) 07/2024 - 03/2002
333	Inflammation (Inflammations) 05/2024 - 01/2004
205	Neoplasm Metastasis (Metastasis) 05/2024 - 03/2005
205	Infections 05/2024 - 04/2003
142	Hepatocellular Carcinoma (Hepatoma) 01/2024 - 08/2003
140	Breast Neoplasms (Breast Cancer) 05/2024 - 11/2002
110	Colorectal Neoplasms (Colorectal Cancer) 03/2024 - 06/2002
106	Fibrosis (Cirrhosis) 05/2024 - 03/2002
97	Obesity 03/2024 - 07/2002
94	Carcinogenesis 02/2024 - 01/2008
92	Carcinoma (Carcinomatosis) 04/2024 - 03/2002
91	Hypertension (High Blood Pressure) 04/2024 - 03/2002
90	Lung Neoplasms (Lung Cancer) 03/2024 - 04/2006
88	Hypoxia (Hypoxemia) 05/2024 - 01/2004
84	Wounds and Injuries (Trauma) 04/2024 - 01/2002
83	Insulin Resistance 10/2023 - 05/2003
81	COVID-19 12/2024 - 01/2020
79	Urinary Bladder Neoplasms (Bladder Cancer) 05/2024 - 04/2003
78	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 05/2024 - 12/2004
70	Prostatic Neoplasms (Prostate Cancer) 03/2024 - 01/2003
66	Stomach Neoplasms (Stomach Cancer) 05/2024 - 03/2003
65	Body Weight (Weight, Body) 07/2024 - 02/2005
65	Pain (Aches) 03/2024 - 07/2007
62	Type 2 Diabetes Mellitus (MODY) 06/2023 - 03/2003
59	Glioma (Gliomas) 12/2023 - 12/2004
57	Colitis 03/2024 - 06/2007
52	Ovarian Neoplasms (Ovarian Cancer) 01/2024 - 01/2004
51	Sepsis (Septicemia) 04/2024 - 11/2006
51	Pancreatic Neoplasms (Pancreatic Cancer) 03/2024 - 03/2008
50	Renal Cell Carcinoma (Grawitz Tumor) 03/2024 - 06/2008
50	Stroke (Strokes) 02/2024 - 08/2003
47	Ischemia 01/2024 - 01/2002
46	Cardiovascular Diseases (Cardiovascular Disease) 10/2023 - 04/2005
45	Alzheimer Disease (Alzheimer's Disease) 05/2024 - 08/2006
44	Myocardial Infarction 12/2024 - 06/2004
42	Metabolic Syndrome (Dysmetabolic Syndrome X) 05/2024 - 06/2005
42	Liver Cirrhosis (Hepatic Cirrhosis) 04/2024 - 05/2006
42	Colonic Neoplasms (Colon Cancer) 01/2024 - 05/2004
42	Pneumonia (Pneumonitis) 10/2023 - 03/2010
41	Asthma (Bronchial Asthma) 10/2023 - 03/2009
40	Hemorrhage 02/2024 - 01/2003
39	Atherosclerosis 05/2024 - 03/2004
38	Adenocarcinoma 02/2023 - 10/2007
37	Necrosis 02/2024 - 03/2005
34	Reperfusion Injury 04/2024 - 06/2003
34	Leukemia 02/2024 - 03/2002
33	Heart Failure 04/2024 - 04/2013

Drug/Important Bio-Agent (IBA)

382	Proteins (Proteins, Gene)FDA Link 04/2024 - 03/2002
264	Biomarkers (Surrogate Marker)IBA 05/2024 - 06/2005
150	CytokinesIBA 05/2024 - 11/2004
148	MicroRNAs (MicroRNA)IBA 04/2024 - 03/2007
125	Messenger RNA (mRNA)IBA 01/2024 - 01/2004
118	Long Noncoding RNAIBA 03/2024 - 03/2012
111	Glucose (Dextrose)FDA LinkGeneric 03/2024 - 07/2002
99	RNA (Ribonucleic Acid)IBA 04/2024 - 01/2004
91	DNA (Deoxyribonucleic Acid)IBA 04/2024 - 04/2002
82	VaccinesIBA 12/2023 - 04/2002
75	EnzymesIBA 04/2024 - 11/2004
73	LipidsIBA 04/2024 - 11/2006
72	Therapeutic UsesIBA 05/2024 - 07/2003
70	Interleukin-6 (Interleukin 6)IBA 04/2024 - 11/2004
66	Insulin (Novolin)FDA Link 01/2024 - 05/2003
66	Small Interfering RNA (siRNA)IBA 08/2023 - 02/2008
61	Cisplatin (Platino)FDA LinkGeneric 07/2024 - 11/2008
60	AntigensIBA 04/2024 - 03/2002
58	Reactive Oxygen Species (Oxygen Radicals)IBA 05/2024 - 02/2009
56	CollagenIBA 05/2024 - 08/2003
55	Peptides (Polypeptides)IBA 04/2024 - 09/2004
52	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 03/2024 - 03/2002
51	Triglycerides (Triacylglycerol)IBA 05/2024 - 07/2003
51	Anti-Bacterial Agents (Antibiotics)IBA 05/2024 - 02/2003
51	C-Reactive ProteinIBA 01/2024 - 06/2006
46	Transcription Factors (Transcription Factor)IBA 05/2024 - 05/2006
45	Indicators and Reagents (Reagents)IBA 05/2024 - 02/2005
43	Doxorubicin (Adriamycin)FDA LinkGeneric 07/2024 - 02/2008
43	CholesterolIBA 05/2024 - 06/2005
43	CreatinineIBA 04/2024 - 08/2007
43	CateninsIBA 02/2024 - 10/2010
41	Immune Checkpoint InhibitorsIBA 05/2024 - 01/2018
40	Oxygen (Dioxygen)IBA 05/2024 - 08/2006
40	AntioxidantsIBA 04/2024 - 05/2008
39	LipopolysaccharidesIBA 04/2024 - 12/2002
39	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 04/2024 - 07/2003
38	LigandsIBA 01/2024 - 04/2003
37	Blood Glucose (Blood Sugar)IBA 05/2024 - 04/2005
37	Circular RNAIBA 05/2024 - 10/2015
37	AlbuminsIBA 04/2024 - 11/2006
37	InflammasomesIBA 02/2024 - 01/2013
36	AntibodiesIBA 05/2024 - 09/2004
35	1-phenyl-3,3-dimethyltriazene (PDT)IBA 05/2024 - 02/2011
35	Phosphotransferases (Kinase)IBA 01/2023 - 11/2003

Therapy/Procedure

615	Therapeutics 05/2024 - 03/2002
187	Drug Therapy (Chemotherapy) 07/2024 - 12/2004
85	Immunotherapy 05/2024 - 09/2004
61	Radiotherapy 09/2023 - 12/2004
43	Photochemotherapy (Photodynamic Therapy) 05/2024 - 04/2006
43	Length of Stay 01/2024 - 11/2006
38	Lasers (Laser) 05/2024 - 07/2007
38	Transplantation 02/2024 - 12/2004
33	Aftercare (After-Treatment) 05/2024 - 11/2005